If you are taking anticoagulant medicine (blood thinners), the amount of vitamin K in your diet may affect how well these medicines work. Little vitamin K is lost from foods with ordinary cooking. If you eat a balanced diet containing these foods, you should be getting all the vitamin K you need. Vitamin K is found in various foods including green leafy vegetables, meat, and dairy products. Vitamin K is necessary for normal clotting of the blood. They are needed in only small amounts and usually are available in the foods that you eat. Vitamins are compounds that you must have for growth and health. Although antidotes against anticoagulant treatment are widely available, our analysis shows that in only a very small number of patients a direct, or slow-acting antidote to reverse the anticoagulant effect was used.Medically reviewed by. Vitamin K was more frequently given in case of a higher international normalized ratio value.
Antidotes were statistically significantly more frequently given in Canada as compared to other participating countries. The use of antidotes was comparable for initial and long-term treatment. Vitamin K was given to 23 (1.2%) patients, one (0.05%) patient received protamin sulfate and seven (0.4%) patients received fresh frozen plasma. Of the patients with at least one major hemorrhage, 19 (41.3%) received an antidote. Some form of antidote was given to 26 (14.4%) patients with a hemorrhage. We investigated 1877 patients treated for venous thromboembolism included in three large clinical trials, of which 181 (9.6%) had a total of 225 adjudicated bleeding episodes 46 hemorrhages being designated as major.
Interestingly, it is unknown how often the use of an antidote is necessary in clinical practice. Several new anticoagulants have been developed that are likely to have some risk of bleeding complications, for which no specific antidotes are available. When a bleeding complication occurs during therapy with heparin or vitamin K antagonists, there is an option to give a specific antidote.
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